Neoadjuvant Systemic Therapies in Bladder Cancer

Neoadjuvant chemotherapy in bladder cancer

The use of neoadjuvant chemotherapy is an important element in the management of advanced bladder cancer. While definitive surgical management of locally advanced disease remains the gold standard of treatment, evidence over the years has repeatedly and consistently demonstrated the survival benefits of presurgical systemic chemotherapy. Incorporation of neoadjuvant chemotherapy into the treatm...

Neoadjuvant chemotherapy for bladder cancer.

Occult distant micrometastasis at the time of radical cystectomy leads predominantly to distant failures in patients with locally advanced muscle-invasive transitional cell carcinoma of the bladder. Cisplatin-based combination chemotherapy enhances survival in patients with metastatic urothelial cancer. Studies evaluating adjuvant chemotherapy have been limited by inadequate statistical power. ...

[Neoadjuvant chemotherapy in muscle-invasive bladder cancer].

Radical cystectomy is the standard treatment for patients with muscle-invasive bladder cancer. Bladder cancer is a chemoresponsive disease and should be dealt with in a multimodality approach. Neoadjuvant chemotherapy is intended for patients with operable clinical stage T2 to T4a muscle-invasive disease to improve survival. Meta-analysis of cisplatin-containing combination neoadjuvant chemothe...

Neoadjuvant Systemic Therapy in Breast Cancer

[Neoadjuvant systemic therapy in breast cancer].

Neoadjuvant (preoperative) systemic therapy is a good possibility for the treatment of symptomatic breast cancers of the locoregional stage. Chemotherapy or hormone therapy chosen according to the characteristics of the primary tumor, result in the regression of the tumor in the majority of the cases, favoring breast conserving surgery thereafter. The long-term effects of neoadjuvant systemic t...